what's Amyloidosis?

In medicine, amyloidosis is a non-specific term that refers to a number of different diseases collectively called amyloidoses. Amyloids are proteins whose secondary structure changes, causing the proteins to fold in a characteristic form, the beta-pleated sheet.^[1] When the normally soluble proteins fold to become amyloids, they become insoluble and deposit in organs or tissues, disrupting normal function.^[2][3] Different types of amyloidoses have different signs and symptoms depending on where and in which organs the amyloid proteins aggregate. Amyloidoses can be inherited or acquired.^[4]