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Thứ Ba, 5 tháng 5, 2020

Kawasaki disease

Kawasaki disease (KD), also known as Kawasaki syndrome, is an acute febrile illness of unknown etiology that primarily affects children younger than 5 years of age. The disease was first described in Japan by Tomisaku Kawasaki in 1967, and the first cases outside of Japan were reported in Hawaii in 1976.
Clinical signs include fever, rash, swelling of the hands and feet, irritation and redness of the whites of the eyes, swollen lymph glands in the neck, and irritation and inflammation of the mouth, lips, and throat.
KD is a leading cause of acquired heart disease in the United States. Serious complications include coronary artery dilatations and aneurysms. The standard treatment, intravenous immunoglobulin and aspirin, substantially decreases the development of these coronary artery abnormalities.
KD occurs worldwide, with the highest incidence in Japan, and it most often affects boys and younger children. KD may have a winter-spring seasonality, and community-wide outbreaks have been reported occasionally. In the continental United States, population-based and hospitalization studies estimate an incidence of KD ranging from 9 to 19 per 100,000 children under 5 years of age. In the year 2000, approximately 4248 hospitalizations with KD were reported among children under 18 in the US, of which 3277 (77%) were for children under 5 years of age. In 2009, the estimated number of hospitalizations with KD was 5447 (standard error [SE]=297), 4040 (SE=227) for children under 5 years of age.

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